Clinical trials are the key to the development of safe, effective health technology.
We partner with leading health providers in NSW and across the world to conduct clinical trials and studies that translate our research in to solutions that directly improve the lives of patients.
Image X’s dedicated clinical trials team provides the infrastructure and expertise needed to navigate ethics approvals, governance requirements and clinical study coordination across translational stages.
Current Clinical Trials
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LEARN: Learning Environment for Artificial intelligence in Radiotherapy New technology
The LEARN Study is investigating a new approach to real-time image-guided radiotherapy called markerless target tracking. Current methods for managing tumour…
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REACT: Respiratory Adaptive Computed Tomography
A Pilot Feasibility Study on the Use of Real-Time Gated 4DCT for Lung Cancer Radiation Therapy The primary objective of the…
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ROCK-RT: Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy
Radio-opaque contrast agents for liver cancer targeting This observational study will investigate the properties of image files standardly collected during radiation…
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VENTURE: Ventilation using radiographic examination
A pilot study to compare functional lung imaging techniques for the reduction of toxicity in functional avoidance radiotherapy The goal of this observational validation study is to determine the…
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Real-Time IGRT: a Master Trial Assessing the Technical Feasibility of First-In-Human Real-Time Image Guided Radiation Therapy Methods
A master trial assessing the technical feasibility of first-in-human real-time image guided radiation therapy methods The goal of this clinical trial…
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POPPY: Post-Operative Prediction of PulmonarY function
A pilot study to assess the benefit of incorporating regional ventilation information in the prediction of post-operative lung function for lung…
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VITaL: A Randomised Controlled Trial Investigating Ventilation Imaging to Improve the Quality of Life for Patients With Lung Cancer Treated With Radiation Therapy
Improving quality of life for patients with lung cancer treated with radiation therapy. This trial is testing a new treatment planning…
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MANGO: Magnetic resonance imaging of hypoxia for radiation treatment guidance in glioblastoma multiforme
Using imaging biomarkers of hypoxia to improve diagnostic and prognostics in GBM management. This study is designed to evaluate the role…
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MAGIK: Markerless Image Guidance Using Intrafraction Kilovoltage X-ray Imaging
This trial will use implanted markers to determine the feasibility of Markerless Image Guidance using Intrafraction Kilovoltage X-ray Imaging. It is…
VITaL Clinical Trial
Information for people who are considering taking part in the VITaL Clinical Trial.
Research Translation
Discover how Image X technologies move from research and development into clinical deployment and patient care.
For International Clinical Trials Day 2021, we prepared a short video about the work we do, and how much we value the patients and trial teams helping us to improve the gold standard of cancer treatment.
Completed Clinical Trials
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CHIRP: Collection of Head Images during Radiotherapy
The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and neck cancer. This objective will be achieved by comparing X-ray images collected during each treatment session with those obtained from the planning CT scan. Secondary objectives include (1) the use of the collected X-ray images to…
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BRAVEHeart: Breast Radiotherapy Audio Visual Enhancement for Sparing the Heart
Saving the heart from damage during breast cancer radiation therapy. We have developed a device to help patients manage Deep Inspiration Breath Hold (DIBH) – a technique where patients take a deep breath and hold it while radiation therapy is being delivered. Filling the lungs with air increases the distance between the target of radiation therapy (a lung or breast tumour) and the heart. This reduces the chance of the heart tissue…
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SPARK: Stereotactic Prostate Adaptive Radiotherapy utilising Kilovoltage intrafraction monitoring
Prostate motion during radiotherapy treatment delivery may shift the tumour outside the beam, simultaneously reducing target dose and exposing normal tissues to potentially damaging radiation doses. SPARK seeks to validate the use of Kilovoltage Intrafraction Monitoring (KIM) to manage intrafraction motion in the Stereotactic Body Radiotherapy (SBRT) treatment of low to intermediate risk cases of prostate cancer. SPARK is a phase II multicentre, single armed, two stage study that will measure cancer…
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LIGHT-SABR – Phase I Feasibility study of Lung Cancer Radiotherapy using Real-time Dynamic Multileaf Collimator Adaptation and Radiofrequency Tracking
In this investigation, patients being treated with Stereotactic Body Radiotherapy (SBRT) for lung cancer will receive a new treatment. Beacons will be implanted into the patients’ lung to allow Multi Leaf Collimator (MLC) tracking equipment to precisely follow the movement of the lung. The difference between tracking tumour movement with MLC versus the current standard method will be compared to identify any variances. Audio-visual (AV) Biofeedback will also be used to regulate…
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ADAPT – Adaptive CT acquisition for personalised thoracic imaging
In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient’s breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the dynamic patient we are able to acquire personalised images of a patients lungs for radiotherapy treatments.Study size: 30 patientsSites: Liverpool Hospital, Macarthur HospitalCollaborating Group: TROG Cancer…
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LARK – Liver Ablative Radiotherapy utilising Kilovoltage Intrafraction Monitoring
The LARK trial will look at treatment outcomes and treatment efficiency when incorporating KIM with SABR to treat eligible patients with primary or secondary liver cancer. Participants will have fiducial markers inserted around their tumours to allow the KIM system to track tumour movement as the patient breathes. Project status: Open to recruitment.Study size: 46 patientsSites: Westmead Hospital, Nepean Hospital, Princess Alexandra Hospital.Collaborating Group: TROG Cancer ResearchContact: Doan Trang Nguyen [email protected]
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Nano-X – Patient experience and acceptance of horizontal rotation
Nano-X is a new radiotherapy machine designed and built in Sydney, consisting of a patient rotation system together with a radiotherapy system. Nano-X proposes to utilise patient rotation to substantially decrease the cost and size of conventional radiotherapy machines. In this trial, we will use the Nano-X patient rotation system only, without the radiotherapy system, to rotate patient volunteers to determine their level of acceptance. Project status: Open to recruitment.Study size: 100…
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AVIATOR: Audio-Visual Investigation Advancing Thoracic Radiotherapy
This investigation will involve a technological assessment of the AV biofeedback system in a clinical setting. Such an investigation will involve an assessment of patient and technician experience with AV biofeedback, looking at patient benefits, impact on image quality and treatment margins. This study will be performed across 7 radiation oncology departments across NSW and ACT, promoting the widespread clinical implementation of AV biofeedback. Performing this investigation across 7 departments will also…